Everett at Mansfield, Friday, Sep. 14, 7 p.m. —The two-time defending D1 state champions face a Mansfield team with D2 championship aspirations. Senior quarterback Damani Scott could even give Everett’s speedy defense issues.
Xaverian at Catholic Memorial, Friday, Sep. 28, 7 p.m. — The Knights have an athletic defense and a sage veteran now on the sideline in John DiBiaso. Will that be enough to stop the Hawks’ patented smash-mouth offense?
Lincoln-Sudbury at Melrose, Friday, Sep. 14, 7 p.m. —The Division 2 finalist will have an early test against the defending Division 4 state champion. A big and physical Warriors squad will look to embrace those attributes against a Red Raider squad that features speed.
King Philip at Mansfield , Friday, Sep. 28, 7 p.m. — Will the Hockomock League title be decided in this last September matchup?
Tewksbury at BC High, Friday, Sep. 21, 7 p.m. — The defending Division 3 North champ Redmen will be challenged by a BC High squad entering Week 3 under new coach Jonathan Brillo.
Hingham at Duxbury, Friday, Oct. 5, 7 p.m. — Duxbury has won 10 straight Patriot League titles. The Dragons knocked Hingham off twice last season, including a thrilling 14-13 come-from-behind win in the regular-season finale.
Wayland at Hopkinton, Friday, 7 p.m. — These two teams clashed on opening night, with the Hillers hanging on for an 18-14 victory. Hopkinton went on to capture the D4 South title. This could be a D4 semifinal preview.
Wilmington at Melrose, Friday, Sep. 28, 7 p.m. — Until dethroned, Melrose reigns over the Middlesex Freedom League, but Wilmington could prove to be a difficult test for the defending state champions.
Dennis-Yarmouth at Marshfield, Friday, Oct. 12, 7 p.m. — In the final year of the Atlantic Coast League, the two perennial conference powers meet in a contest that could decide the league title. The reigning D5 state champion Dolphins dominated the Rams in last season’s clash.
Scituate at East Bridgewater, Friday, Oct. 19, 7 p.m. — A duel of two of the best QBs in the South, Aidan Sullivan (Scituate) and Liam LeVangie (EB).
Norwell at Rockland, Friday, Oct. 12, 7 p.m. — These two Division 6 South semifinalists from 2017 meet in the penultimate game of the regular season.
Tech Boston at Latin Academy, Friday, Sep. 21, 6 p.m. – A clash of two of the best teams in the Boston City League. This will go a long way in determining the BCL North champ.
Pope John at St. John Paul II, Saturday, Oct. 13 — This North/South battle could have major implications in the next-to-last week of the regular season.Globe correspondents on the school staff contributed to this report.